An Intact Small Animal Model of Myocardial Ischemia-Reperfusion: Characterization

1 of Metabolic Changes by Hyperpolarized C MR Spectroscopy 2 3 Running Title: 60 characters including spaces: 4 Reperfusion metabolism in a novel intact small animal model 5 6 Hikari A.I. Yoshihara; 1,4,5 Jessica A.M. Bastiaansen; 3,4 Corinne Berthonneche; 7 Arnaud Comment; Juerg Schwitter 1,5 8 9 1. Division of Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland 10 2. Cardiovascular Assessment Facility, Lausanne University Hospital (CHUV), Lausanne, 11 Switzerland 12 3. Institute of Physics of Biological Systems, Swiss Federal Institute of Technology (EPFL), 13 Lausanne, Switzerland 14 4. Center for Biomedical Imaging (CIBM), Lausanne, Switzerland 15 5. Cardiac MR Center, Lausanne University Hospital (CHUV), Lausanne, Switzerland 16 17 Correspondence: J. Schwitter, MD, Division of Cardiology and CMR Center, Rue du Bugnon 18 46, CH-1011 Lausanne, Switzerland; Tel: +41 21 314 0012; Fax: +41 21 314 0013; Email: 19 [email protected] 20 21 Word Count: 7810 Abstract: 250 words, 22 23 Articles in PresS. Am J Physiol Heart Circ Physiol (October 9, 2015). doi:10.1152/ajpheart.00376.2015